{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Sheet1"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":33,"n_cols":18,"rows_kept":33,"merged":[[0,0,0,17],[1,0,27,0],[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,3,6],[2,7,3,7],[2,8,3,8],[2,9,3,9],[2,17,3,17],[4,1,9,1],[4,2,9,2],[4,3,9,3],[4,4,9,4],[4,5,9,5],[4,6,9,6],[4,7,9,7],[4,8,9,8],[4,9,9,9],[4,11,9,11],[4,13,9,13],[4,14,9,14],[4,16,8,16],[4,17,9,17],[11,1,14,1],[11,2,14,2],[11,3,14,3],[11,4,14,4],[11,5,14,5],[11,6,14,6],[11,7,14,7],[11,8,14,8],[11,9,14,9],[11,11,14,11],[11,12,14,12],[11,13,14,13],[11,16,13,16],[11,17,14,17],[15,1,16,1],[15,2,16,2],[15,3,16,3],[15,4,16,4],[15,5,16,5],[15,6,16,6],[15,7,16,7],[15,8,16,8],[15,9,16,9],[15,11,16,11],[15,12,16,12],[15,17,16,17],[17,1,20,1],[17,2,20,2],[17,3,20,3],[17,4,20,4],[17,5,20,5],[17,6,20,6],[17,7,20,7],[17,8,20,8],[17,16,19,16],[17,17,20,17],[18,9,20,9],[21,1,25,1],[21,2,25,2],[21,3,25,3],[21,4,25,4],[21,5,25,5],[21,6,25,6],[21,7,25,7],[21,8,25,8],[21,9,25,9],[21,16,25,16],[21,17,25,17],[26,1,27,1],[26,2,27,2],[26,3,27,3],[26,4,27,4],[26,5,27,5],[26,6,27,6],[26,7,27,7],[26,8,27,8],[26,9,27,9],[26,11,27,11],[26,12,27,12],[26,13,27,13],[26,14,27,14],[26,16,27,16],[26,17,27,17],[28,0,28,17],[29,0,29,17],[30,0,30,17],[31,0,31,10],[32,0,32,17]],"flags":["formulas_cached_only"]}
["Table 2. Summary of the longitudinal studies on the association between diet and dental caries in  children under 6 years old."]
["<= 6 yrs old","id","Author","Year","Country","Sample size","Age (yr)","Follow-up (yr)","Instrument","Outcome measure","Main results","HR1 ","PR2 ","OR3","IRR4","p - value","Significancy","Grading†"]
[null,1,"Ghazal",2019,"USA",98,5.9,6,"Questionnaire","DMFS ","Water consumption; HR =0.44 (0.26–0.74), p=0.002  to having caries in the first permanent tooth;  Others: previous primary caries experience, HR=4.54 (1.53–13.45), p=0.006. ",0.44,{"$nulls":3},0.002,"Sig.",21]
[{"$nulls":10},"Frequency of daily consumption of milk,  100% juice, added-sugar beverages,  candy and/or gum consumption ",{"$nulls":5},"NS"]
[null,2,"Llena#",2018,"Spain",206,10,5,"NR","DMFT and DMFT (6st)  (cavitated vs. noncavitated)/ICDAS II\n","PR of cavitated/non-cavitated lesions (6st) with sweet consumption",null,"_0.59 ",null,null,0.04,"Sig.",20]
[{"$nulls":10},"PR of cavitated/non-cavitated lesions (6st)  with soft drinks",null,"_0.58 ",null,null,0.04]
[{"$nulls":10},"PR of cavitated lesions (6st) with soft drinks",null,"_0.69",null,null,0.03]
[{"$nulls":10},"PR of cavitated/non-cavitated lesions (all permanent teeth) with soft drink",null,"_0.76",null,null,0.03]
[{"$nulls":10},"PR of cavitated lesions (all permanent teeth) with soft drink,",null,"_0.58 ",null,null,0.04]
[{"$nulls":10},"Sweets, pastary, Snacks",{"$nulls":5},"NS"]
[null,3,"Karjalainen",2015,"Finland (Turku, STRIP study) ",148,3,13,"4-day food record"," D3 MFT, d3 mft  (cavitation)","Mean d3mft/D3MFT with sucrose intake; statistically different between those with Sucrose Intake<10%E vs. >=10%E (1.63±0.26 vs 2.82±0.51, p=0.014) in 9 yrs old subjects; Mean of caries-free age (the mean of years while the permanent dentition stayed caries-free in <10% vs. >=10% group):  10.8 vs 9.9 yrs [HR=1.22 (0.77-1.93) p=0.396]",{"$nulls":4},"0.014a","Sig.",20]
[null,4,"Hooley",2012,"Australia (LSAC study)",4149,"4–5  ",4,"24-hour recall","dmft (yes / no)","OR of sweet drink consumption with dental problems (wave 3)",{"$nulls":3},1.1,0.01,"Sig.",20]
[{"$nulls":10},"OR of  fatty food consumption with dental problemes (wave 2)",{"$nulls":3},1.1,0.02]
[{"$nulls":10},"OR of fatty food consumption with dental problems (wave 3)",{"$nulls":3},1.13,0.01]
[{"$nulls":10},"OR of sweet drink consumption with dental problems (wave 2)",{"$nulls":5},"NS"]
[null,5,"Chankanka",2011," USA, Iowa Fluoride Study (IFS)",198,5,4,"3-day diaries","new caries (cavitated: D2-3 /d2-3) & F/f","OR of new cavitated caries (5-9 yrs) was significantly associated with  having greater processed starch at snack time  (OR=3.87, p=0.07)",null,null,3.87,null,0.07,"Sig.** ",20]
[{"$nulls":10},"milk; 100% juices; juice drinks; powder-sugared beverages;\nregular (sugared) soda pop; diet soda pop; sports drinks; and water. sugar-based desserts; candy; added sugar (table sugar, honey, brown sugar, etc); baked starch with sugar (cookies, cake, etc); unsweetened cereals; presweetened cereals; unprocessed starches (boiled potato, bread, rice, etc)",{"$nulls":5},"NS"]
[null,6,"Lim",2008,"USA",369,"3-5",2," FFQ  (2000 Block Kids)","ICDAS$/d2mfs/D2mfs","IRR of low soft drink consumption at baseline changed to high with caries increment",{"$nulls":3},1.75,null,"Sig.",20]
[{"$nulls":9},"New Filled Surface","IRR of consuming low soft drink at baseline changed to high with new filled surface",{"$nulls":3},2.76]
[{"$nulls":10},"IRR of consuming high soft drink consumption at baseline and follow up with new filled surface",{"$nulls":3},2.68]
[{"$nulls":10},"Total Sugar Intake (low-middle-high)§",{"$nulls":5},"NS"]
[null,7,"Ollila",2007,"Finland (Otitis media)",175,2,7,"Questionnaire","Initial caries (Enamel) vs. Manifest caries (Dentine) ","Survival analysis of diet and caries onset:  In children who consumed candies more than once a week the mean survival time of primary 2nd molars were 7.83 vs. 10.06 yrs,  p<0.001. ",{"$nulls":4},"<0.001","Sig.",20]
[{"$nulls":10},"In children who consumed candies more than once a week in the onset of caries in tooth 55  ","6.83b",{"$nulls":3},"<0.001"]
[{"$nulls":10},"In children who consumed candies more than once a week in the onset of caries in tooth 75","8.18b",{"$nulls":3},"<0.001"]
[{"$nulls":10},"In children who consumed candies more than once a week in the onset of caries in tooth 16","3.8b",{"$nulls":3},"0.025"]
[{"$nulls":10},"Mean survival time of  permanent 1st molars in children who consumed candies more than once a weekwere 10.03 vs. 10.21 yrs, p=0.067",{"$nulls":4},0.067]
[null,8,"Ruottinen",2004,"Finland (Turku, STRIP study)",66,"at birth (infancy) ",10,"Food Frequency Form","dmft/DMFT","DMFT (mean ± SD):  High sucrose intake group vs. Low sucrose intake group  1.4 ± 2.0 vs. 0.5 ± 1.1 (p= 0.01)",{"$nulls":4},0.01,"Sig.",16]
[{"$nulls":10},"DMFT+dmft (mean ± SD): High sucrose intake group vs. Low sucrose intake 3.9± 3.9 vs. 1.9 ± 2.5 (p=0.032)  ",{"$nulls":4},0.03]
["1 Hazard Ratio, 2 Prevalence Ratio,  3 Odds Ratio,  4Incidence Rate Ratio."]
[" a Mean d3mft/D3MFT with Sucrose Intake, b According to the Cox’s multivariate model."]
[" †STROBE checklist, # Historical cohort, NR: not reported, FFQ: Food Frequency Questionnaire, NS: not significant, * Significant (p<0.05),  **Significant (p≤0.07)."]
["$ Caries were assessed according to the International Caries Detection and Assessment System (ICDAS). § Cariogenic solid food with both outcome,\n"]
["λ Mann-Whitney U test."]